Dermophisiologique
Italian professional skincare brand founded in 1989 by Loretta Pizio and Carolina Ambra Redaelli — 150+ physiological formulations, 7 international patents, the proprietary D5SF® method, B Corp certified since 2015 (the first B Corp cosmetic company in the world). Made in Italy, in-house manufactured, distributed through professional beauty centres, spas and oncology support programmes in 40+ countries.
Dermophisiologique — Dermophisiologique S.r.l. Società Benefit
Dermophisiologique is an Italian professional skincare brand founded in 1989 in Northern Italy, dedicated to developing cosmetic products and treatment protocols that work in complete harmony with the natural physiology of human skin. Founded and still led by two women — Loretta Pizio and Carolina Ambra Redaelli (Director of R&D) — the brand has been built for over 40 years on a single promise: science, respect for the skin and environmental responsibility, in equal measure.
Over more than four decades of dermatological and scientific research, Dermophisiologique has assembled a portfolio of more than 150 exclusive formulations protected by seven international patents. They are distributed through professional beauty centres, spas, wellness facilities and oncological support programmes worldwide, and the brand is recognised as one of the most certified and credentialed professional skincare companies in the world.
Every product is developed according to the proprietary D5SF® formulation method — a physiological approach that respects the skin's natural biological balance and guarantees maximum tolerability even for sensitive, reactive, compromised or post-treatment skin, while delivering visible and lasting results. Since 2000, all formulations are free from mineral oils, petroleum derivatives, synthetic dyes, added parabens and alcohol — a clean standard that predates the wider clean beauty movement by many years.
What Dermophisiologique brings to the table
Proprietary D5SF® Physiological Formulation Method
Dermophisiologique's D5SF® method is a registered, physiological approach that respects the skin's natural biological balance. Every formulation is engineered to deliver maximum tolerability for sensitive, reactive, compromised or post-treatment skin while still producing visible, lasting cosmetic results — the rare combination that defines the brand's credibility with dermatologists and clinical operators worldwide.
40+ Years of Italian Dermatological Research
Founded in 1989 and led continuously by Loretta Pizio and Carolina Ambra Redaelli. A portfolio of more than 150 exclusive formulations, seven international patents, and efficacy tests certified by the University of Pavia — the brand's research depth is its strongest competitive asset for distributors seeking clinically credible partners.
Clean Formulation Standard Since 2000
No mineral oils, no petroleum derivatives, no synthetic dyes, no added parabens, no alcohol — and no harmful preservatives, artificial colours or synthetic fragrances. A clean standard adopted more than two decades before the broader clean beauty movement, embedded in the brand's positioning and regulatory record.
World-First B Corp Certified Professional Cosmetic Company
Certified B Corp since 2015 — the first B Corp certified professional cosmetic company in the world — and Italian Società Benefit since 2016. Fourth recertification in 2024 with a score of 104.1 (median for ordinary businesses: 50.9). Member of the B Corp Beauty Coalition, ISO 9001-2015 certified, PEG-free and nickel-tested. A globally unique credential that powers distributor communications in sustainability-led and purpose-driven markets.
Ontherapy® — Specialised Line for Oncological Skin Support
A specialised cosmetic line developed to support skin undergoing pharmacological and oncological treatments. Unique clinical-grade proposition for professional beauty centres, oncology departments and wellness operators working with compromised or post-treatment skin. A significant differentiator for distributors serving healthcare-adjacent and clinical channels.
Complete Face & Body Professional System
Chrono Age® anti-aging, Aqualife hydration, Sensiderm for sensitive and reactive skin, D White brightening and depigmentation, Resurface exfoliation and resurfacing. The portfolio addresses all major professional treatment needs and supports both cabin protocols and home care prescriptions for clinics, spas and beauty centres.
Body Contouring & Balneotherapy Ranges
Adipexert / CellulHiTech body contouring lines (localised fat, cellulite, tone, stretch marks, breast and décolleté care) and Balneoil balneotherapy range for thermal and hydro-therapy environments. The natural fit for spas, thermal centres and wellness operators building a differentiated body and hydro-therapy service menu.
Sustainable Packaging & Production
100% recycled FSC-certified paper packaging, water-based inks, biodegradable rinse-off formulas (OECD 301F tested), raw materials of certified EEC origin, all production Made in Italy in-house, and the website hosted on verified green infrastructure. A complete sustainability narrative that supports premium positioning with eco-conscious operators and guests.
Why international buyers choose this brand
- First B Corp certified professional cosmetic company in the world — B Corp 2015, fourth recertification 2024 (score 104.1 vs median 50.9); member of B Corp Beauty Coalition.
- 40+ years of Italian dermatological research · 150+ exclusive formulations · 7 international patents · University of Pavia efficacy certification.
- Proprietary D5SF® physiological formulation method — maximum tolerability for sensitive, reactive, compromised and post-treatment skin.
- Clean formulation standard since 2000 — no mineral oils, petroleum derivatives, synthetic dyes, parabens or alcohol.
- Comprehensive face and body professional system covering anti-aging, hydration, sensitive skin, brightening, body contouring, balneotherapy and resurfacing.
- Ontherapy® line for oncological and pharmacological skin support — unique clinical-grade differentiation in the professional skincare market.
- Balneoil balneotherapy range and Adipexert/CellulHiTech body contouring lines — natural fit for spa, thermal and wellness operators.
- Sustainable packaging (FSC recycled paper, water-based inks, OECD-301F biodegradable formulas), green hosting, full Made in Italy in-house production.
- Active spa and wellness channel with a partner-centre network and a consumer-facing Find-a-SPA service on the brand website.
- Founded and led by women — strong purpose-driven brand narrative for international markets where ESG and impact credentials are decisive.
International distribution & partnership programme
Dermophisiologique is positioned for international distribution through professional beauty, spa, wellness and specialised clinical channels. The brand offers distributors a differentiated and values-aligned offer — built on 40+ years of scientific credibility, a clean formulation standard that predates the clean beauty movement, internationally recognised certifications (B Corp, ISO 9001-2015, University of Pavia efficacy) and a strong purpose-driven identity. The specialised Ontherapy® line opens healthcare-adjacent distribution opportunities in oncology support programmes and clinical dermatology practices; the body contouring, balneotherapy and sensitive skin ranges complement a full spa and wellness portfolio.